Product Candidate
BDTH2
BDTH2 (N,N′-bis-(2-mercaptoethyl) isophthalamide, NBMI, emeramide) is a thiol-redox antioxidant and metal chelator that exhibits a wide range of beneficial properties for cellular health. With its chemical structure, BDTH2 can penetrate cell membranes and cross the blood-brain barrier, ensuring its antioxidant effects are not limited to specific body areas.
One of its primary functions is the scavenging and reduction of hydroxyl free radicals, which are highly reactive and can disrupt the normal redox status of cells, potentially causing damage and oxidative stress. BDTH2‘s versatility as a chelator is equally impressive. In vitro studies have demonstrated its selective ability to bind to toxic metal ions, particularly arsenic, and non-essential metals such as lead, cadmium, and uranium.
By forming stable complexes with these harmful metals, BDTH2 can effectively remove them from the body and mitigate their toxic effects. The two sulfhydryl groups of cysteamine moieties in BDTH2‘s structure play a pivotal role, allowing flexibility and rotation to accommodate various toxic soft acid metal ions.
One of the most promising aspects of BDTH2 is its remarkable safety profile. Clinical trials on humans have shown no evidence of adverse effects, highlighting its potential as a safe and effective therapeutic agent.
The research conducted by Bjørklund et al. (2020) has shed light on the beneficial properties of BDTH2, particularly in the context of arsenic intoxication and metal chelation (1). As a result, BDTH2 holds significant promise in the realm of oxidative stress management, metal detoxification, and cellular health maintenance.
As the scientific community continues to explore the full potential of BDTH2, it may emerge as a vital tool in combating the detrimental effects of toxic metals and oxidative stress, offering new avenues for improving human health and well-being.
Reference
1. Bjørklund G, Oliinyk P, Lysiuk R, Rahaman MS, Antonyak H, Lozynska I, Lenchyk L, Peana M. Arsenic intoxication: general aspects and chelating agents. Arch Toxicol 2020; 94: 1879-1897.
