Product Candidate

CalmZen

CalmZen is a nutraceutical formulation developed to address the interplay between stress, anxiety, and overall well-being. It integrates magnesium and L-theanine, two compounds with established roles in modulating neurophysiological pathways relevant to stress response and relaxation.

Magnesium participates in diverse intracellular processes, including enzymatic reactions, cellular energy metabolism, and neurotransmission. Of particular relevance to stress management is its involvement in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis, a critical neuroendocrine system implicated in stress response modulation. Preclinical and clinical evidence suggests that magnesium deficiency may exacerbate stress-related symptoms, while supplementation appears to confer anxiolytic and sleep-enhancing effects.

Complementing magnesium is L-theanine, an amino acid predominantly found in tea leaves, mainly green tea. Unlike sedative agents, L-theanine exerts anxiolytic and relaxing effects without inducing sedation. Its mechanism of action involves modulation of neurotransmitter activity, particularly gamma-aminobutyric acid (GABA)ergic transmission, leading to enhanced inhibitory neurotransmission and attenuation of stress-related neuronal excitability. Additionally, L-theanine has been associated with the upregulation of serotonin and dopamine levels, contributing to mood modulation and cognitive function improvement.

Combining magnesium and L-theanine in CalmZen underscores a synergistic stress management and relaxation approach. Magnesium facilitates GABA binding to its receptors, augmenting GABAergic neurotransmission and promoting neuronal inhibition, while L-theanine potentiates GABAergic activity and modulates serotonergic and dopaminergic pathways, collectively fostering a state of tranquility and mental well-being.

CalmZen offers various therapeutic benefits, encompassing anxiety and stress symptom reduction, relaxation and tranquility promotion, sleep quality and duration enhancement, and improved cognitive function and mental clarity. Such multifaceted effects align with the nature of stress management and well-being promotion.

The recommended therapeutic dose of CalmZen for adult patients consists of 1-2 capsules, each containing 400 mg of magnesium and 200 mg of L-theanine. Oral administration with water, preferably alongside a meal, is advised to optimize bioavailability. Dividing the dose throughout the day may optimize stress management and relaxation efficacy.

While generally well-tolerated, individuals with severe renal impairment or those undergoing concomitant medication regimens should exercise caution and consult with healthcare professionals before initiating CalmZen supplementation. Proper storage in a cool, dry environment away from light and moisture is essential to preserve product integrity.