In allergy and immunology, Björklund Pharma offers Aller-San, an herbal tablet for allergy relief, and Immunita Forte, a potent immune-supporting supplement with medicinal mushroom extracts. The company is also investigating thymosin beta 4 for inflammatory conditions.
Product Candidates
Aller-San
Aller-San is an herbal tablet with anti-inflammatory and antihistamine effects. It can help reduce symptoms such as sneezing, runny nose, itchy eyes, and other common allergy symptoms. The pill contains butterbur, quercetin, bromelain, and ginger, which have anti-inflammatory and antihistamine effects.
The ingredients in Aller-San may work together to provide greater relief from allergy symptoms than what they have when used separately. When used together, quercetin and butterbur extract synergistically reduce allergy symptoms, and bromelain improves the absorption of quercetin.
Aller-San has some potential contraindications. Butterbur extract can cause gastrointestinal effects such as upset stomach, nausea, and diarrhea. Quercetin can interact with certain medications, including blood thinners and anti-inflammatory drugs. Bromelain can cause side effects in some people, such as stomach upset, diarrhea, and skin rashes. Ginger can cause gastrointestinal side effects such as upset stomach, nausea, and diarrhea.
Immunita Forte
Immunita Forte is a potent immune-supporting supplement formulated with a synergistic blend of extracts from medicinal mushrooms known for their immunomodulatory properties. These mushrooms include reishi (Ganoderma lucidum), shiitake (Lentinula edodes), maitake (Grifola frondosa), cordyceps (Cordyceps sinensis or Cordyceps militaris), and turkey tail (Trametes versicolor).
Each of these mushrooms contains bioactive compounds recognized for their ability to modulate immune function. Reishi, for instance, is rich in beta-glucans and triterpenes that stimulate immune cell activity and regulate cytokine production, thereby enhancing immune responses. Similarly, shiitake and maitake mushrooms are abundant in beta-glucans and polysaccharides, which bolster immune function and contribute to overall health. Cordyceps contains cordycepin and adenosine, compounds that may enhance immune modulation and improve immune responses. Meanwhile, turkey tail mushrooms contain polysaccharopeptides known for their immune-enhancing effects, which support immune function and promote overall well-being.
The synergistic interactions between these ingredients amplify their individual immune effects. Research suggests that combining medicinal mushroom extracts can enhance immune function through complementary mechanisms of action. For example, beta-glucans from one mushroom species may synergize with polysaccharides from another, resulting in enhanced activation of immune cells and regulation of immune responses. Moreover, certain compounds in one mushroom extract may increase the bioavailability or activity of bioactive constituents from other mushrooms in the blend, further potentiating their immune-modulating effects.
Immunita Forte is recommended for immune support to address various health challenges. It serves as an adjunctive therapy in conditions characterized by weakened immunity, such as recurrent infections, immune-related disorders, and general immune system maintenance for overall well-being.
The appropriate dosage of Immunita Forte should be tailored to individual needs and health status. The supplement is available in convenient forms such as capsules or liquid extracts, and dosage regimens should be determined in consultation with a healthcare professional.
While generally well-tolerated, individuals with known allergies to mushrooms or any of the ingredients in Immunita Forte should avoid its use. Pregnant or lactating women and individuals with underlying health conditions should consult a healthcare professional before incorporating the product into their regimen.
Inbio ImmuneBoost
Inbio ImmuneBoost is a dietary supplement formulated by Björklund Pharma with a blend of herbal extracts known for their immunomodulatory properties to support overall immune health. These herbs include Echinacea (Echinacea purpurea), Astragalus (Astragalus membranaceus), Andrographis (Andrographis paniculata), elderberry (Sambucus nigra), and curcumin (Curcuma longa).
Echinacea is a well-studied herb recognized for its ability to enhance immune function. It contains bioactive compounds such as alkamides, polysaccharides, and flavonoids that stimulate various aspects of the immune system, including the activation of macrophages and the production of cytokines critical for immune response. Echinacea is commonly used to support immune health and combat respiratory infections.
Astragalus is valued for its immunostimulatory effects, particularly in supporting immune response and resilience. Active compounds in astragalus, such as astragalosides and polysaccharides, enhance the activity of immune cells like macrophages, T-cells, and natural killer (NK) cells. Astragalus also exhibits antioxidant properties that contribute to overall immune function and vitality, making it a frequent component of traditional Chinese medicine to support immune health and combat fatigue.
Andrographis contains andrographolide, a bioactive compound with potent immunomodulatory and antiviral properties. Research suggests that andrographolide can inhibit viral replication, reduce inflammation, and enhance immune cell function. Andrographis is commonly used to support respiratory health and strengthen immune defenses during cold and flu season.
Elderberry is rich in flavonoids, particularly anthocyanins like cyanidin and quercetin, which have potent antioxidant and anti-inflammatory effects. Elderberry inhibits viral replication, reduces the severity and duration of respiratory infections, and supports immune function by enhancing cytokine production and modulating immune cell activity. It is a popular natural remedy for boosting immune health and combating colds and flu.
Curcumin, the active compound in turmeric, is known for its potent anti-inflammatory, antioxidant, and immunomodulatory properties. Curcumin suppresses inflammatory pathways, regulates immune cell function, and enhances antioxidant defenses. Extensive research supports its potential to support immune health and reduce inflammation associated with various immune-related conditions, promoting overall immune balance and resilience.
Inbio ImmuneBoost is carefully formulated to deliver standardized concentrations of these herbal extracts in a convenient liquid form for optimal absorption and efficacy. Each ingredient is selected based on scientific evidence to support immune function and well-being.
Thymosin Beta 4 in Inflammatory Conditions
Björklund Pharma AS focuses on thymosin beta 4 (Tβ4), a naturally occurring and highly conserved molecule with potent anti-inflammatory and wound healing properties (1). Tβ4 stimulates dermal wound healing, suppresses pro-inflammatory signaling pathways and gene expression profiles, ameliorates end-organ tissue damage, and promotes repair.
Tβ4 is clinically relevant in a wide array of systemic inflammatory conditions. It inhibits the activation and nuclear translocation of transcription factor nuclear factor kappa B (NFκB), a major regulator of the inflammatory response.
References
1. Bjørklund G, Dadar M, Aaseth J, Chirumbolo S. Thymosin β4: a multi-faceted tissue repair stimulating protein in heart injury. Curr Med Chem 2020; 27(37): 6294-6305.
Allergy and Immunology
In allergy and immunology, Björklund Pharma offers a range of natural solutions designed to relieve allergy symptoms and support overall immune health. Our products combine traditional herbal ingredients with modern scientific research to provide effective, non-prescription options for managing allergies and enhancing immune function.
Product Candidates
Aller-San
Aller-San is an herbal tablet formulated to relieve common allergy symptoms such as sneezing, runny nose, and itchy eyes. The product contains a synergistic blend of butterbur, quercetin, bromelain, and ginger, which reduce inflammation and histamine reactions. This combination offers a natural and practical approach to managing seasonal allergies and other allergic conditions. Read More
Immunita Forte
Immunita Forte is a potent immune-supporting supplement made with medicinal mushroom extracts, including reishi, shiitake, maitake, cordyceps, and turkey tail. These mushrooms are known for their immunomodulatory properties, enhancing immune function through complementary mechanisms. Immunita Forte is ideal for those looking to strengthen their immune system, especially in the face of recurrent infections or immune-related disorders. Read More
Inbio ImmuneBoost
Inbio ImmuneBoost is a dietary supplement formulated to support overall immune health. It combines well-known herbal extracts such as Echinacea, Astragalus, Andrographis, elderberry, and curcumin, each selected for their immunomodulatory and anti-inflammatory properties. This supplement is particularly beneficial during cold and flu season, helping to boost the body’s defenses against infections. Read More
Thymosin Beta 4 in Inflammatory Conditions
Thymosin Beta 4 is an advanced therapeutic candidate with potent anti-inflammatory and wound-healing properties. While still under investigation, it shows promise for managing systemic inflammatory conditions by suppressing pro-inflammatory signaling pathways and promoting tissue repair. Read More
RespiraGuard (New Addition)
RespiraGuard is a natural respiratory support supplement designed to address respiratory allergies and support clear breathing. It includes ingredients like quercetin, nettle leaf, and bromelain, which are known for reducing histamine responses and supporting respiratory function. This product is for individuals with seasonal respiratory allergies or allergic rhinitis. Read More
